Fig. 6.

miR-223 induced cisplatin resistance by suppressing FBXW7. a Cell viability of A549 and NCI-H1299 cells cultured in different concentrations of cisplatin following treatment with the miR-223 inhibitor plus transfection with FBXW7 siRNA or FBXW7 siRNA alone. *P < 0.05; **P < 0.01 vs. control. b Real-time PCR was used to validate the efficiency of the miR-223 inhibitor or FBXW7 siRNA. c, d Western blot of FBXW7, LC3-I/II, and SQSTM1 in NSCLC cells treated with the miR-223 inhibitor plus transfection with FBXW7 siRNA, FBXW7 siRNA alone, or the scrambled control. *P < 0.05; **P < 0.01 vs. NC