Table 2.
Pathways related to neutrophil migration predicted to be differentially activated by proteins in T2- and T17-EVs
| T17-EVs | T2-EVs | |||
|---|---|---|---|---|
| Pathway | Activation z-score | Implicated proteins | Activation z-score | Implicated proteins |
| Migration of neutrophils | 1.929 | AKT2, CD47, FN1, SAA1, TNFRSF1A | ||
| Quantity of neutrophils | 1.504 | CD47, CSF3, GNAI2, LYN, PRKCD, SLPI, TNFAIP3, TNFRSF1A | ||
| Cell movement of neutrophils | 1.367 | AKT2, CD47, CFB, CSF3, FN1, GNAI2, LYN, PIGR, PLTP, SAA1, TNFAIP3, TNFRSF1A, TNIP1 | −0.287 | BST1, CD36, CD44, GSN, NOS2, PLCB3, PLTP |
| Infiltration by neutrophils | 0.468 | CFB, CSF3, PLTP, TNFAIP3, TNFRSF1A, TNIP1 | −1.77 | CD36, CD44, NOS2, PLCB3, PLTP |
| Immune response of neutrophils | −0.134 | CD47, CSF3, FN1, LYN, SAA1 | ||
| Adhesion of neutrophils | −0.655 | CD44, NOS2, PLCB3, PLTP | ||
This table contains all pathways containing the term “neutrophil” that were given an activation z-score using Ingenuity Pathway Analysis on the EV proteomics. Activation z-score > 0 suggests activated pathway, Activation z-score < 0 suggests inhibited pathway. See data for implicated proteins in Fig. 6.