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. Author manuscript; available in PMC: 2020 Jun 19.
Published in final edited form as: Cell Rep. 2020 May 19;31(7):107662. doi: 10.1016/j.celrep.2020.107662

Figure 4. srbc-48 Mutation Enhances that Animal Susceptibility to Infection-Associated Dendrite Degeneration in a Cell-Autonomous Manner.

Figure 4.

(A) Representative photomicrographs of srbc-48 animals expressing srbc-48 and gfp under the control of the odr-1 promoter, strain AY146 (srbc-48(ac23);Podr-1::srbc-48::SL2::GFP), after 24 h of P. aeruginosa infection. The scale bars represent 20 µm.

(B) Quantification of the dendrite degeneration phenotype in control, srbc-48(ac23), and strain AY146 (srbc-48(ac23);Podr-1::srbc-48::SL2::GFP) animals. The black symbols represent individual experiments (n = 5; animals per condition = 50). Control versus srbc-48(ac23) (p < 0.0001) and srbc-48(ac23) versus strain AY146 (p < 0.0001) via one-way ANOVA test.

(C) Representative photomicrographs of strain NC1686 (wdIs51), which expresses GFP in PVD neurons, crossed with srbc-48(ac23) animals after exposure to P. aeruginosa for 24 h (n = 3; animals per condition = 20). The scale bars represent 100 µm.

(D) Representative photomicrographs of strain CX3553 (kyIs104), which expresses GFP in AWB neurons, crossed with srbc-48(ac23) animals after exposure to P. aeruginosa for 24 h (n = 3; animals per condition = 20). The scale bars represent 20 µm.