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. Author manuscript; available in PMC: 2020 Jun 19.
Published in final edited form as: Cell Rep. 2020 May 26;31(8):107687. doi: 10.1016/j.celrep.2020.107687

Figure 3. SIX2 Regulates Important b Cell Genes and Gene Sets.

Figure 3.

(A) Heatmap of 1,000 most differentially expressed genes between stage 6 cells transduced with sh-ctrl and sh-SIX2–1 by p value. n = 6.

(B) Volcano plot showing all differentially expressed genes. Genes with at least a 2-fold change (FC) are in black. Genes of particular interest are highlighted.

(C) Selected enriched gene sets for important β cell processes from the Molecular Signatures Database. Also included 2 custom gene sets comprising 76 genes identified in Veres et al. (2019) and the top 424 genes identified in Nair et al. (2019) positively correlating with time and maturation in vitro. NES, normalized enrichment score.

(D) Enrichment plots from the shown gene sets.

(E) FCs from genes within enriched b cell-related gene sets.

See also Figure S3 and Tables S1–S3.