Table 3.
Sensitivity analyses for Scr, BUN, UAER, ACR, hs-CRP, IL-6, and MDA.
| Outcome | Study | Data with study removed | ||||||
|---|---|---|---|---|---|---|---|---|
| MD/SMD (95% CI) | I2 | Z | P | |||||
| Scr | ||||||||
| Xiong et al., 2013 | –22.17 (–23.94, –20.41) | 97 | 24.67 | <0.00001 | ||||
| Xu, 2014 | –17.74 (–19.33, –16.15) | 98 | 21.88 | <0.00001 | ||||
| Liu et al., 2014 | –18.45 (–20.08, –16.82) | 98 | 22.21 | <0.00001 | ||||
| Zhao et al., 2015 | –17.18 (–18.76, –15.61) | 98 | 21.40 | <0.00001 | ||||
| Fu and Shao, 2018 | –15.65 (–17.45, –13.84) | 98 | 16.99 | <0.00001 | ||||
| Chen et al., 2018 | –13.40 (–15.04, –11.76) | 96 | 16.02 | <0.00001 | ||||
| Liang and Wang, 2019 | –15.45 (–17.32, –13.58) | 98 | 16.19 | <0.00001 | ||||
| Chen et al., 2019 | –17.06 (–18.64, –15.48) | 98 | 21.16 | <0.00001 | ||||
| BUN | ||||||||
| Liu et al., 2014 | –1.49 (–2.32, –0.65) | 87 | 3.48 | 0.0005 | ||||
| Zhao et al., 2015 | –1.66 (–2.54, –0.77) | 81 | 3.66 | 0.0003 | ||||
| Fu and Shao, 2018 | –1.34 (–2.27, –0.42) | 84 | 2.84 | 0.005 | ||||
| Chen et al., 2018 | –1.03 (–1.62, –0.44) | 74 | 3.45 | 0.0006 | ||||
| Liang and Wang, 2019 | –1.44 (–2.42, –0.45) | 87 | 2.85 | 0.004 | ||||
| Chen et al., 2019 | –1.62 (–2.58, –0.66) | 87 | 3.32 | 0.0009 | ||||
| UAER | ||||||||
| Xiong et al., 2013 | –1.52 (–2.32, –0.71) | 92 | 3.71 | 0.0002 | ||||
| Xu, 2014 | –2.17 (–3.01, –1.34) | 91 | 5.10 | <0.00001 | ||||
| Liu et al., 2014 | –1.54 (–2.36, –0.72) | 92 | 3.68 | 0.0002 | ||||
| Zhao et al., 2015 | –2.00 (–3.09, –0.92) | 95 | 3.61 | 0.0003 | ||||
| Zhang et al., 2015 | –1.86 (–2.92, –0.80) | 95 | 3.45 | 0.0006 | ||||
| Chen et al., 2019 | –1.96 (–3.09, –0.83) | 95 | 3.40 | 0.0007 | ||||
| ACR | ||||||||
| Zhang and Li, 2014 | –2.06 (–2.62, –1.50) | Not applicable | 7.20 | <0.00001 | ||||
| Fu and Shao, 2018 | –0.83 (–1.27, –0.40) | Not applicable | 3.79 | 0.0002 | ||||
| hs-CRP | ||||||||
| Lu et al., 2014 | –5.43 (–6.94, –3.92) | 56 | 7.05 | <0.00001 | ||||
| Zhang et al., 2015 | –5.98 (–7.73, –4.24) | 67 | 6.72 | <0.00001 | ||||
| Ma and Zhao, 2015 | –6.34 (–7.58, –5.11) | 0 | 10.05 | <0.00001 | ||||
| Fu and Shao, 2018 | –5.52 (–7.14, –3.90) | 59 | 6.68 | <0.00001 | ||||
| Chen et al., 2018 | –5.34 (–6.75, –3.94) | 51 | 7.46 | <0.00001 | ||||
| IL-6 | ||||||||
| Lu et al., 2014 | –10.05 (–15.30, –4.79) | 93 | 3.75 | 0.0002 | ||||
| Zhang et al., 2015 | –13.16 (–20.66, –5.67) | 97 | 3.44 | 0.0006 | ||||
| Ma and Zhao, 2015 | –11.77 (–19.79, –3.75) | 96 | 2.88 | 0.004 | ||||
| Fu and Shao, 2018 | –14.60 (–19.98, –9.22) | 93 | 5.32 | <0.00001 | ||||
| Chen et al., 2018 | –13.12 (–20.33, –5.92) | 96 | 3.57 | 0.0004 | ||||
| MDA | ||||||||
| Zhang and Li, 2014 | –2.78 (–5.33, –0.23) | 97 | 2.14 | 0.03 | ||||
| Fu and Shao, 2018 | –1.07 (–1.91, –0,22) | 86 | 2.48 | 0.01 | ||||
| Liang and Wang, 2019 | –2.36 (–5.75,1.04) | 98 | 1.36 | 0.17 | ||||
Scr, serum creatinine; BUN, blood urea nitrogen; UAER, urinary albumin excretion rate; ACR, albumin-to-creatinine ratio; hs-CRP, hypersensitive C-reactive protein; IL-6, Interleukin-6; MDA, malondialdehyde.