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Remdesivir inhibits EV71 replication post virus entry. (A) Schematic representation of the different treatment methods. Cells were pretreated with remdesivir (B), coadsorbed remdesivir and EV71 (C), remdesivir after EV71 adsorption that was removed after virus entry (D), or remdesivir after virus entry (E), and at 24 hpi, the EV71 viral RNA copy number was quantified by qRT-PCR (mean ± SD, n = 3). *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.
