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. 2020 Jun 12;11:1105. doi: 10.3389/fmicb.2020.01105

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Copyright © 2020 Ye, Yao, Dong, Ye, Wang, Liu, Ma, Zhang, Qi, Yang, Wang, Zhang, Cheng, Lv, Xu, Lei and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Remdesivir inhibits EV71 replication at the viral transcription stage. (A) Schematic representation of reverse transcription and PCR protocol for conventional real-time PCR (top) and tagged primer-mediated qRT-PCR (bottom). The tag within the tagged RT primer is shown in green, and the amplified products contained a portion of the tag and cDNA. (B,C) Synthesis of EV71 cRNA (normalized to the actin expression level) was inhibited by remdesivir (mean ± SD, n = 3). P > 0.05, *P < 0.05, **P < 0.01, and ***P < 0.001.