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. 2020 Jun 12;11:1105. doi: 10.3389/fmicb.2020.01105

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Copyright © 2020 Ye, Yao, Dong, Ye, Wang, Liu, Ma, Zhang, Qi, Yang, Wang, Zhang, Cheng, Lv, Xu, Lei and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Remdesivir exhibits broad-spectrum inhibition of enterovirus replication. (A) Phylogenetic analyses of the human enterovirus amino acid sequence. EV-A is marked in light blue, EV-B is marked in gold, EV-C is marked in orange, and EV-C is marked in green. CVB3 (B) and EV70 (C) RNA synthesis was inhibited by remdesivir (mean ± SD, n = 3). *P < 0.05, ***P < 0.001, and ****P < 0.0001.