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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Exp Neurol. 2019 Oct 30;323:113094. doi: 10.1016/j.expneurol.2019.113094

Table 1.

MiRNAs modulate BBB function in stroke

Disorders miRNAs Study subject Proposed contribution to BBB Target gene/Mechanism Refs
Ischemic stroke Negative
miR-150 Rat Increases BBB permeability Reducing the claudin-5 expression by binding to angiopoietin receptor Tie-2 (Fang et al., 2016)
miR-210 Rat MiR-210 disrupts BBB integrity Suppressing the expression of junction proteins by directly binding to occludin and β-catenin (Ma et al., 2017)
miR-143 Mouse The inhibited miR-143 activity maintains BBB integrity Regulating TJs expression by binding to Hectd 1 (Bai et al., 2018)
miR-130a Rat MiR-130a increases BBB permeability Down-regulating the expression of occludin by binding to homeobox A5 (Wang et al., 2018)
miR-15a/16–1 mouse MiR-15a/16–1 impairs BBB integrity Directly binding to claudin-5 (Zuo et al., 2019)
miR-34a bEnd.3 cell line MiR-34a enhances BBB permeability Impairing mitochondrial function in ECs by binding to CYCS (Bukeirat et al., 2016)
miR-155 HBMECs MiR-155 impairs endothelial monolayer integrity Reducing the expression of ZO-1 by directly binding to claudin-1 (Pena-Philippides et al., 2018)
Positive
miR-149–5p Rat MiR-149–5p reduces BBB permeability Enhancing N-cadherin expression by binding to S1PR2 (Song et al., 2018)
miR-539 Rat MiR-539 preserves BBB integrity Mediating BBB structure by binding to MMP-9 (Fan et al., 2018)
miR-21 Rat MiR-21 alleviates I/R-induced BBB disruption Blocking the MAPK signaling pathway by binding to MAPK2K3 (Yao et al., 2018)
miR-132 Mouse MiR-132 preserves BBB integrity Regulating the degradation of VE-cadherin and β-catenin by directly binding to MMP-9 (Zuo et al., 2019)
Hemorrhagic stroke Positive
miR-126–3p Rat MiR-126–3p preserves BBB integrity and function Inhibiting neural inflammation by targeting PIK3/Akt pathway (Xi et al., 2017)
miR-132 Mouse MiR-132 mitigates BBB permeability Inhibiting the expression of ZO-1 and claudin-5 (Zhang et al., 2017)
miR-27a-3p Rat MiR-27a-3p attenuates brain edema and BBB leakage Protecting against post-ICH complications by directly binding to AQP11 (Xi et al., 2018)