Box 16. Recommendations.

Specific IgE determination is recommended within 2 weeks – 6 months following a reaction.

In the case of patients with severe life-threatening reactions, sIgE determination should be performed prior to skin tests and drug provocation tests if possible.

Specific IgE needs to be assessed in the overall context of findings. Since the detection of positive IgE antibodies to beta-lactams is not necessarily of clinical relevance, one can also decide in case of detected specific IgE, in justified cases, to continue in vivo diagnostic testing, including provocation testing to investigate clinical relevance.