Box 18. Recommendations.

The cellular diagnosis of immediate reactions can be considered as an optional diagnostic step, in particular prior to skin and provocation testing in high-risk patients, e.g., with a history of high-grade anaphylaxis and if other testing procedures are neither available nor feasible.

Performing the relevant test with different concentrations of the drug to be tested is recommended.

The time window for carrying out cellular diagnosis of immediate reactions should ideally be within 14 days – 6 months following the hypersensitivity reaction.