Box 22. Recommendation.

DPT is recommended once other allergy diagnostic tests have been completed, after an individual risk–benefit analysis has been carried out.

If possible, the patient should be exposed to the suspected drug in its original formulation.

In justified exceptional cases, DPT can be performed even without prior diagnostic testing if urgently required for the purposes of administering a drug.

In the case of severe immediate reactions that lie many years in the past and one-off normal provocation testing, a re-evaluation (repetition of skin and in vitro tests, followed by provocation tests if normal) may be considered in individual cases with a high degree of suspicion.