. 2020 May 28;4:11–43. doi: 10.5414/ALX02104E

Table 1. Typical time intervals between first use of beta-lactam antibiotics and first onset of symptoms (from [20]).

Hypersensitivity reaction	Time interval
Urticaria, asthma, anaphylaxis	Typically up to 1 h, rarely up to 6 h after initial drug administration
Maculopapular drug exanthema	4 – 14 Days after initial drug administration^a
Fixed drug reaction	1 – 12 Hours after initial drug administration
AGEP	1 – 2 Days after initial drug administration^a
SJS/TEN	2 – 8 Weeks after initial drug administration^a

^aThe time interval in renewed reactions is typically shorter compared to initial reactions. In maculopapular drug exanthema, reaction typically after 6 h – 4 days; typical time interval after repeat reactions in AGEP, SJS, TEN, DRESS not investigated . AGEP = acute generalized exanthematous pustulosis; SJS = Stevens-Johnson syndrome; TEN = toxic epidermal necrolysis; DRESS = drug reaction with eosinophilia and systemic symptoms.