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. Author manuscript; available in PMC: 2021 May 15.
Published in final edited form as: J Immunol. 2020 Apr 3;204(10):2829–2839. doi: 10.4049/jimmunol.1901227

Figure 1, SP-A deficient mice are more susceptible to IL-13 challenge than WT mice.

Figure 1,

A) WT and SP-A mice were challenged with IL-13 for 3 consecutive days via oropharyngeal instillation. B) Total cells present in the BAL were examined on day 4 in saline challenged versus IL-13 challenged mice. Differential cell populations were determined by cell staining for macrophages, neutrophils and eosinophils in BAL of C) saline challenged or D) IL-13 challenged mice. E) Muc5AC gene expression was quantified by RT-PCR of lung tissue and represented as fold of the saline treated control. F) PAS scores from IL-13 challenged mice were quantified by lung histological staining. G) KC, H) Eotaxin and I) IL-6 in BALF were quantified by ELISA. J) Representative micrographs of PAS stained lungs in WT and SP-A−/− mice after IL-13 challenge. B-I data were obtained from n=8,8 saline treated and n=20,20 IL-13 treated mice across three separate experiments, *p<0.05, **p<0.01, ***p<0.001.