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. 2020 Feb 27;3(2):161–170. doi: 10.20517/cdr.2019.117

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© The Author(s) 2020.

© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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A novel human TOP2α/90 isoform is overexpressed in acquired resistance to TOP2α-targeted drugs etoposide, mitoxantrone, and amsacrine. A: TOP2α immunoassay utilizing K562 and K/VP.5^{[35,36,55,56]} cell lysates; B: TOP2α immunoassay utilizing HL-60 and HL-60/MX2^[32,50,51] cell lysates; C: TOP2α immunoassay utilizing HL-60 and HL-60/AMSA^[57] cell lysates. The immunoblots were probed with an antibody specific for the N-terminal portion of TOP2α/170 (i.e., amino acids 14-27, denoted N-terminal Ab). (A) Image is from Figure 2A published originally in the Journal of Pharmacology and Experimental Therapeutics; Kanagasabai et al.^[35], 2017. TOP2α: topoisomerase IIα