Table 1.
Descriptive characteristics for the whole cohort
| Descriptive Characteristics | Whole Cohort n=86 (%) | RT-naïve Cohort n=68 | Re-RT Cohort n= 18 |
|---|---|---|---|
| Age | |||
| <70 years | 65 (76) | 52 (76) | 13 (72) |
| >=70 years | 21 (24) | 16 (24) | 5 (28) |
| Gender | |||
| Male | 56 (65) | 44 (65) | 12 (67) |
| Female | 30 (35) | 24 (35) | 6 (33) |
| Primary site | |||
| Nasal cavity or ethmoid sinus | 52 (60) | 45 (66) | 7 (39) |
| Other sinuses | 34 (40) | 23 (34) | 11 (61) |
| Histology | |||
| Squamous cell carcinoma | 35 (41) | 27 (40) | 8 (44) |
| Adenocarcinoma | 4 (4) | 4 (6) | 0 (0) |
| Adenoid cystic carcinoma | 11 (13) | 8 (12) | 3 (17) |
| Sinonasal undifferentiated carcinoma | 6 (7) | 6 (9) | 0 (0) |
| Olfactory neuroblastoma | 7 (8) | 5 (7) | 2 (11) |
| Neuroendocrine | 5 (6) | 4 (6) | 1 (6) |
| Other | 18 (21) | 14 (20) | 4 (22) |
| T category | |||
| T1–2 | 24 (35) | 18 (26) | 6 (33) |
| T3–4 | 62 (64) | 50 (74) | 12 (67) |
| N category | |||
| N0 | 70 (81) | 56 (82) | 14 (78) |
| N1 | 5 (6) | 2 (3) | 3 (17) |
| N2 | 10 (12) | 9 (13) | 1 (5) |
| N3 | 1 (1) | 1 (2) | 0 |
| Surgical Resection | |||
| No | 43 (50) | 33 (49) | 10 (56) |
| Yes | 43 (50) | 35 (51) | 8 (44) |
| Endoscopic | 16 (37) | 16 (46) | 0 (0) |
| Open | 27 (63) | 19 (54) | 8 (100) |
| Margin | |||
| Positive or Close | 26 (60) | 19 (54) | 7 (88) |
| Negative | 15 (35) | 14 (40) | 1 (12) |
| Unclear | 2 (5) | 2 (6) | 0 (0) |
| Proton Technique | |||
| 3DCPT | 40 (47) | 30 (44) | 10 (55) |
| IMPT | 46 (53) | 38 (56) | 8 (45) |
| Radiation dose (RBE) | |||
| Median (Range) | 70 (45–86) | 70 (45–86) | 68 (54–76) |
| <70 CGE | 34 (40) | 24 (35) | 10 (56) |
| ≥70 CGE | 52 (60) | 44 (65) | 8 (44) |
| Neck radiation | |||
| Yes | 41 (48) | 38 (59) | 1 (6) |
| No | 45 (52) | 28 (41) | 17 (94) |
| Chemotherapy | |||
| No | 31 (36) | 22 (32) | 9 (50) |
| Yes | 55 (64) | 46 (68) | 9 (50) |
| Cisplatin based | 41 (75) | 35 (76) | 6 (67) |
| Carboplatin based | 9 (16) | 9 (20) | 0 (0) |
| Cetuximab | 3 (5) | 1 (2) | 2 (22) |
| Other regimen | 2 (4) | 1 (2) | 1 (11) |
| 2 Year LC | 82% [73–92] | 83% [73–94] | 77% [57–100] |
| 2 Year DC | 84% [76–93] | 84% [75–95] | 80% [62–100] |
| 2 Year DFS | 70% [60–82] | 74% [63–87] | 54% [34–87] |
| 2 Year OS | 77% [68–88] | 81% [71–92] | 66% [46–92] |