Table 3.
ROI Beta Values Across Age, Group, and Age by Group Interactions During fMRI Fluency Task
| ROI | MNI Coordinates | NT | ASD | F | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Young N = 14 M (SD) | Middle-aged N = 20 M (SD) | Young N = 17 M (SD) | Middle-aged N = 24 M (SD) | Age (ES; p) | Group (ES; p) | Age* Group ( partial η2; p) | ||||
| LIFG: BA 44 | −52 | 14 | 28 | 1.88 (0.93) | 1.41 (0.79) | 1.83 (0.90) | 1.99 (0.80) | 0.54 (0.16; .46) | 1.77 (0.38; .19) | 2.50 (0.04; .12) |
| L. SSA: BA 6a | −8 | 12 | 51 | 1.39 (0.59) | 1.03 (0.53) | 1.49 (0.95) | 1.18 (0.55) | 4.26* (0.67; .008) | 0.56 (0.15; .41) | 0.02 (<0.001; .97) |
| L. Cerebellum | −20 | −76 | −50 | 0.12 (0.86) | 0.20 (0.55) | −0.22 (1.05) | −.09 (0.63) | 0.34 (0.15; .56) | 2.95 (0.42; .09) | 0.02 (<0.001; .89) |
| R. Cerebellum | 20 | −76 | −50 | 1.36 (0.79) | 0.88 (0.79) | 0.99 (1.14) | 0.81 (0.81) | 2.53 (0.36; .17) | 1.02 (0.20; .32) | 0.53 (0.008; .47) |
| L. Thalamusb | −16 | 0 | 10 | 0.32 (0.50) | 0.10 (0.33) | 0.41 (0.71) | 0.06 (0.49) | 5.33* (0.69; .005) | 0.05 (0.12; .55) | 0.23 (0.002; .74) |
|
L. Superior temporal gyrus: BA 22 c |
−52 | −42 | 14 | 0.01 (0.41) | 0.25 (0.62) | −0.10 (0.54) | 0.25 (0.72) | 3.78* (0.49; .05) | 0.12 (0.08; .73) | 0.12 (0.002; .73) |
| L. Angular Gyrus: BA 39d |
−46 | −66 | 36 | −1.11 (0.70) | −0.92 (0.49) | −0.77 (0.65) | −0.45 (0.71) | 2.94 (0.08; .09) | 7.10* (0.63; .01) | 0.19 (.003; .67) |
| L Posterior cingulate (DMN): BA 23 e | −7 | −52 | 22 | −0.86 (0.52) | −0.85 (0.66) | −0.42 (0.66) | −0.48 (0.83) | 0.03 (0.63; .87) | 5.99* (0.59; .01) | 0.05 (0.001; .82) |
a:
Young < Middle-age
b:
Young > Middle-age
c:
Young < Middle-age
d:
TD < ASD
e:
TD > ASD
*
p values uncorrected for multiple comparisons
A*G: Age by Group interaction; L.: Left; R.: Right; BA: Brodmann Area; LIFG: Left Inferior Frontal Gyrus (Pars Opercularis) SSA: Supplementary Speech Area; DMN: Default Mode Network