Skip to main content
. 2020 Jun 19;15(6):e0234773. doi: 10.1371/journal.pone.0234773

Fig 1. Flowchart for the comparison of pre-S genotyping results between liver tissues and plasma in this study.

Fig 1

Liver tissue and plasma specimens collected from 30 HBV-related HCC patients (1 for each patient) were analyzed by IHC and NGS for detection of pre-S mutants, respectively. Comparative analysis of the pre-S genotyping results revealed that 22 out of 30 (73%) patients had matched IHC and NGS results but the other 8 (27%) did not. Further analysis of another 1 liver tissue specimen obtained from each of the 8 patients by IHC increased the number of the patients with matched results up to 28 (93%) (as indicated by dashed lines). The Abbreviations: HBV, hepatitis B virus; HCC, hepatocellular carcinoma; IHC, immunohistochemistry; NGS, next-generation sequencing.