Table 2.
Variable | No. | 2-Year cumulative rate, % | Univariate |
Multivariate |
||
---|---|---|---|---|---|---|
HR (95%CI) | P-valuea | HR (95%CI) | P-valuea | |||
Age | 0.009 | 0.016 | ||||
<60 years | 705 | 14.1 | 1 | 1 | ||
⩾60 years | 603 | 19.3 | 1.42 (1.09–1.86) | 1.46 (1.07–1.99) | ||
CA-125 levels | 0.003 | 0.025 | ||||
⩽35 IU/L | 132 | 5.8 | 1 | 1 | ||
>35 IU/L | 1061 | 17.0 | 2.52 (1.33–4.76) | 2.38 (1.11–5.07) | ||
Thrombocytosisb | 0.0001 | 0.032 | ||||
No | 860 | 13.8 | 1 | 1 | ||
Yes | 434 | 22.3 | 1.66 (1.26–2.18) | 1.42 (1.03–1.96) | ||
Residual tumour size after surgery | 0.028 | 0.52 | ||||
>1 cm | 353 | 20.2 | 1 | 1 | ||
⩽4 cm | 897 | 13.6 | 0.72 (0.53–0.97) | 0.89 (0.63–1.27) | ||
Stage-specific histologic type | <0.0001 | |||||
Advanced SOC | 836 | 16.2 | 1 | 1 | ||
Advanced OCCC | 106 | 43.1 | 2.74 (1.92–3.92) | 3.38 (2.28–5.01) | <0.0001 | |
Early-stage SOC | 102 | 6.4 | 0.54 (0.28–1.03) | 0.80 (0.38–1.68) | 0.55 | |
Early-stage OCCC | 264 | 11.9 | 0.73 (0.50–1.06) | 1.23 (0.77–1.95) | 0.39 |
Abbreviations: HR, hazard ratio; CI, confidence interval; CA-125, cancer antigen 125; SOC, serous ovarian carcinoma; OCCC, ovarian clear cell carcinoma.
The log-rank test was used for univariate analysis and Cox proportional hazards regression modelling was used for multivariate analysis.
Platelet count ⩾ 400 × 109/L.