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. 2020 Jun 17;8(1):e000785. doi: 10.1136/jitc-2020-000785

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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In vitro cell killing assay of the delta-like 3 (DLL3) bispecific antibody. All the tested cell lines were stably transduced to constitutively express a fire fly luciferase reporter gene (ffLuc2). Ten thousand cancer cells were coincubated with two hundred thousand unstimulated peripheral blood mononuclear cells (PBMC) cells for 48 hours in the presence of variable concentrations of the bispecific antibody as indicated. The cell viability was quantified by measuring the intracellular luciferase activity. DLL3-negative A431 was served as a control of the non-specific killing by the bispecific antibody. Statistical comparisons between the A431 control and other cell lines at each bispecific antibody concentration was calculated and labeled on the top of the bar. Data represent mean±SEM.