Table 1. Double Tsuji–Trost Allylation Reactions of bis-Carbonate 16 Catalyzed by Palladium Complexes of Ligands 17a–c.
| Product
ratioa |
||||||
|---|---|---|---|---|---|---|
| Entry | Ligand | 18a | 18b | 18c | 18d | Yieldb |
| 1 | 17c | 45 | 9 | 46 | – | – |
| 2 | 17a | 40 | 49 | 11 | – | 75% |
| 3 | 17b | 37 | – | 63 | – | 70% |
| 4 | (±)-17a/b | 42 | 7 | 51 | – | – |
Ratio of diastereomeric products 18a–d determined by 1H NMR analysis of crude material.
Combined yield of diastereomeric products 18 isolated by chromatography.