Table 1.
Effects of normal sleep vs sleep deprivation
| Measure | Normal sleep, mean (SEM) | Sleep deprivation, mean (SEM) | Mean difference (SEM) | Test statistics |
|---|---|---|---|---|
| Fasting glucose (mmol/l) | 5.34 (0.07) | 5.32 (0.07) | 0.03 (0.07) | t 0.373, p = 0.712 |
| Fasting insulin (pmol/l) | 52.78 (6.25) | 56.25 (5.56) | −3.24 (4.74) | t 0.684, p = 0.501 |
| Fasting, NEFA (mmol/l); n = 8 | 0.53 (0.04) | 0.55 (0.06) | −0.01 (0.06) | t 0.210, p = 0.840 |
| KG (%/min) | 3.7 (0.2) | 3.2 (0.2) | 0.5 (0.2) | t 1.942, p = 0.065 |
| Beta cell response, AIRG (mU/l × min) | 509.7 (32.0) | 504.5 (31.1) | 5.2 (18.4) | t 0.284, p = 0.779 |
| SI (mU−1 min−1) | 6.50 (0.62) | 4.95 (0.51) | 1.55 (0.48) | t 3.243, p = 0.004** |
| DI | 3195 (312) | 2421 (283) | 774 (254) | t 3.049, p = 0.006** |
| SG (%/min) | 0.041 (0.002) | 0.039 (0.002) | 0.002 (0.002) | t 0.926, p = 0.364 |
| Adipo-IR (mmol/l × pmol/l); n = 8 | 31.11 (7.78) | 36.81 (5.76) | −5.72 (8.13) | t − 0.704, p = 0.504 |
| Fasting cortisol (pmol/l); n = 12 | 5.13 (0.68) | 4.00 (0.82) | −1.13 (3.10) | t 1.261, p = 0.233 |
| Fasting adrenaline (pmol/l); n = 12 | 365.8 (67.2) | 322.1 (59.0) | −43.7 (204.2) | t 0.743, p = 0.473 |
| Fasting noradrenaline (pmol/l); n = 12 | 931.0 (251.2) | 834.0 (253.6) | −96.9 (334.0) | t 1.005, p = 0.336 |
| 24 h physical activity (mean counts per h); n = 7 | 273 (52) | 261 (49) | −12 (38) | t 0.326, p = 0.756 |
| Daytime physical activity (mean counts per h); n = 7 | 491 (96) | 481 (102) | −10 (75) | t 0.138, p = 0.895 |
| Night-time physical activity (mean counts per h); n = 7 | 55 (12) | 40 (11) | −15 (22) | t 0.704, p = 0.508 |
Data from all animals after normal sleep and sleep deprivation, after following a chow diet (NS-chow and SD-chow)
n = 24 unless otherwise noted; due to IV issues leading to reduced plasma available for assays, fasting NEFA and Adipo-IR were measured in n = 8 animals, and fasting cortisol, adrenaline and noradrenaline were measured in n = 12 animals
To convert SI values to SI units, multiply by 0.167
Paired samples t test statistic reported with p value;
**
p < 0.01