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. 2020 Jun 19;6(25):eaaz4462. doi: 10.1126/sciadv.aaz4462

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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

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Fig. 2 — (A) Hydrodynamic diameter distribution. (B) Transmission electron micrographs. Scale bars, 50 nm. (C) Nitrogen absorption-desorption isotherms. (D) Pore size distribution. (E) Small-angle x-ray scattering. (F) Zeta potential of MSNs loaded with or without OVA. (G) Encapsulation efficiency (EE) and loading capacity (LC) of OVA. (H) Release of OVA from OVA@MSNs in PBS. Asterisks indicate P values associated with comparisons between OVA@MSNs-L and OVA@MSNs-M or OVA@MSNs-S; pound signs indicate the same P ranges for comparisons between OVA@MSNs-M with OVA@MSNs-S. The significance of the results was analyzed by using one-way analysis of variance (ANOVA). *P < 0.05, **P < 0.01, and ***P < 0.001; #P < 0.05 and ##P < 0.01; ns, not significant. Data are shown as means ± SD (n = 3). All experiments were repeated two to three times.