Table 3.

Base-case predicted clinical and cost outcomes

	Predicted mean
Predicted cumulative incidence of diabetes by age 30 years (diagnosed cases per 10,029 children and adolescents screened)	78
Population average HbA1c at age 30 years used to project long-term complications among those diagnosed with diabetes	9.1%
Discounted ASK screening and intervention costs*	$560,000
Discounted routine screening and intervention costs*	$1,641,000
Discounted DKA treatment costs at diagnosis†	$240,000
Discounted other diabetes complication costs over a lifetime‡	$19,500,000
Discounted total costs for cases diagnosed with type 1 diabetes over a lifetime	$20,300,000
Discounted QALYs for cases diagnosed with type 1 diabetes over a lifetime	2,573

^*Intervention costs include screening costs for the 10,029 children and adolescents screened, repeat confirmation screening costs for all positive cases, and two follow-up visits per year for prediabetes cases until patient is age 18 years.

^†Proportion of patients with a DKA event at diagnosis for all arms = 46%.

^‡Other diabetes complication costs include treatment and management of long-term complications and minor and major hypoglycemic events for the patients that transitioned to have a diagnosis of diabetes.