Table 2.

HRs for the association of blood pressure variables with HF estimated by Cox proportional hazards model in ACCORD (n = 9,383)

	Model 1		Model 2		Model 3
	Age adjustment		Multivariate adjustment		Model 2 + cumulative mean BP
	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
Cumulative mean SBP	1.03 (1.02–1.04)	<0.001	1.02 (1.01–1.04)	0.001	—	—
Cumulative maximum SBP	1.25 (1.19–1.32)	<0.001	1.22 (1.07–1.38)	0.002	1.09 (0.90–1.31)	0.37
CV-SBP	1.24 (1.13–1.35)	<0.001	1.15 (1.04–1.28)	0.009	1.15 (1.03–1.29)	0.01
ARV-SBP	1.26 (1.16–1.37)	<0.001	1.18 (1.06–1.30)	0.002	1.19 (1.07–1.32)	0.001
Cumulative mean DBP	0.99 (0.97–1.00)	0.13	1.00 (0.97–1.03)	0.90	—	—
Cumulative maximum DBP	1.03 (0.92–1.15)	0.63	1.07 (0.93–1.24)	0.35	—	—
CV-DBP	1.27 (1.17–1.38)	<0.001	1.18 (1.06–1.31)	0.003	1.18 (1.06–1.32)	0.003
ARV-DBP	1.24 (1.15–1.34)	<0.001	1.18 (1.06–1.31)	0.002	1.18 (1.06–1.31)	0.002

HRs (95% CI) and P values estimated by Cox proportional hazards model in ACCORD. Those with a history of HF at baseline were excluded. Blood pressure variables that were significant in age-adjusted models (model 1) were further adjusted for baseline factors that showed significant associations in Table 1 (model 2). In model 3, models were additionally adjusted for cumulative mean of blood pressure (BP). Model 3 was not computed if the model 2 HR was not statistically significant. P values <0.05 (bold) are considered significant.