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. 2020 Apr 28;43(7):1537–1545. doi: 10.2337/dc19-2348

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© 2020 by the American Diabetes Association

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/content/license.

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Associations of genetic liability to adult type 2 diabetes with metabolic traits at different early-life stages among ALSPAC offspring. Estimates shown are β-coefficients representing the SD difference in metabolic trait per SD higher GRS for type 2 diabetes, ordered concentrically (inner circle to outer circle) by increasing age at measurement. Six metabolic traits were not measured at the 25-years time point: diacylglycerol, ratio of diacylglycerol to triglycerides, fatty acid chain length, degree of unsaturation, conjugated linoleic acid, and ratio of conjugated linoleic acid to total fatty acids.