Figure 1:

Cytotoxicity of chemotherapy agents in the presence of LC.

A-B: RS4;11 ALL cell viability by trypan blue exclusion (A) and AlamarBlue assay (B) after 72-hour incubation with LC in combination with either ASNase (0.1IU/mL), VCR (2 nM), DNR (20 nM), or DEX (100 nM); n=4. C: Cleaved caspase 3 and full-length caspase protein levels in RS4;11 cells after 24-hour treatment with LC (200 μM) and DNR (n=4). D: Viability of BV173, SEM, and NALM6 measured by trypan blue exclusion after 72-hour treatment with DNR (25 nM, 30 nM, 50 nM, respectively), with or without LC (n=4). Dashed line indicates initial cell number. *, p < 0.05.