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. Author manuscript; available in PMC: 2020 Jun 19.
Published in final edited form as: Gastroenterology. 2020 Feb 4;158(6):1682–1697.e1. doi: 10.1053/j.gastro.2020.01.044

Figure 6. Epigenetically Silenced Genes and Clinical Relevance.

Figure 6

a. List of genes which are preferentially silenced either in Subtype 1 or Subtype 2. b. Correlation between methylation and expression for MGMT gene across all cases from four different subtypes. c. Same as B for CHFR gene. d. Growth inhibition responses of eight primary tumour derived organoids and control gastric organoid (NG088) Drug response to Temozolomide. e. MGMT staining in low (CAM277) and stable (CAM408) expressing tumours and derived organoids (scale bar=100uM). f. Drug classes for which sensitivity is indicated by EAC driver genes with data from the Cancer Biomarkers database.