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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Nat Protoc. 2020 Apr 1;15(5):1690–1706. doi: 10.1038/s41596-020-0303-y

Figure 4. Enhancing the spectra by modifying the capillary tip.

Figure 4

(a) The vesicle diameter varies from 100-500 nm depending on the membrane’s origin, therefore a capillary cut in the standard way (LH panel), may not allow for sufficient exit of vesicles, and may require further opening (RH panel). Scale bar is 1 mm. (b) Scanning electron microscopy of the capillary tips cut in the standard way (LH panel) and further broken (RH panel). Scale bar is 1 μm.