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. Author manuscript; available in PMC: 2021 Jun 20.
Published in final edited form as: Mol Psychiatry. 2019 Dec 20;26(8):3765–3777. doi: 10.1038/s41380-019-0633-8

Figure 1.

Figure 1.

D2R viral overexpression in NAc core increases locomotion. (a) AAV1 vector overexpressing D2R in cre-dependent fashion. (b) mVenus expression in NAc core 6 weeks post infusion at 4x magnification. (c) Diagramatic representation of the maximum (colors) and minimum (grey) spread of D2R-mVenus (orange) and GFP (blue) in the NAc; numbers indicate distance from Bregma; anterior commissure, aca. (d) Total distance traveled in the open field over 30 min by D2R-OENAc and EGFPNAc male and female mice. (e) Distance traveled per 5 min bin in the open field by D2R-OENAc and EGFPNAc male and female mice. (f) Total center distance traveled in the open field over 30 min by D2R-OENAc and EGFPNAc male and female mice. (g) Total number of rearings in the open field over 30 min by D2R-OENAc and EGFPNAc male and female mice. Open field data are pooled for experiments 1 and 2. Mean ± s.e.m, n = 8-12/group, An asterisk indicates a significant effect of virus compared to same sex controls. A pound sign indicates a significant difference between sexes within the same viral condition.