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. 2020 Jun 19;11:3114. doi: 10.1038/s41467-020-16949-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic representation of non-even distribution of epitope spikes on the surface of a viral particle. b Designed, virus-mimicking DOEs for IgG capture and binding. Artificial epitope (digoxin, yellow), DNA origami (gray), modified staple DNA strands (blue and pink), IgGs (bivalent binding, blue; monovalent binding, green). c PeakForce-AFM image for DOE-based capture of IgGs. Scale bar, 100 nm. d Enlarged view of the dashed yellow square in panel c. Scale bar, 20 nm. e A high-resolution HS-AFM image of an Fc and two Fab domains of the bound IgG (upper left, yellow arrows); atomic structure of IgG (Protein Data Bank (PDB) entry 1HZH, upper right); cross-sectional profile of three domains (Fab, blue and Fc, magenta) in a DOE-bound IgG (bottom). Source data are provided as a Source Data file.