Table 1.
Pairwise amino acid sequence identity and similarity of MLKL orthologues over full-length sequence and component domains.
| Species | Mouse identity (similarity) % | Human identity (similarity) % | ||||
|---|---|---|---|---|---|---|
| Full length | 4HB + brace | Pseudokinase | Full length | 4HB + brace | Pseudokinase | |
| Mouse | – | – | – | 61.8 (84.0) | 51.7 (82.6) | 69.3 (86.6) |
| Rat | 85.8 (96.3) | 82.7 (97.1) | 87.9 (96.2) | 62.2 (84.2) | 53.9 (80.3) | 68.1 (87.9) |
| Pig | 60.2 (83.2) | 52.4 (77.5) | 66.1 (87.3) | 63.0 (88.6) | 57.8 (87.2) | 68.3 (91.8) |
| Horse | 63.0 (83.3) | 56.1 (78.1) | 67.6 (87.1) | 65.3 (88.3) | 57.9 (87.4) | 70.2 (89.0) |
| Chicken | 39.4 (66.6) | 31.7 (66.5) | 50.8 (74.8) | 40.2 (70.4) | 32.4 (69.0) | 50.5 (76.0) |
| Tuatara | 39.8 (70.4) | 29.1 (69.8) | 49.1 (76.2) | 41.0 (73.6) | 30.5 (70.2) | 52.9 (79.7) |
| Frog | 36.0 (71.1) | 23.5 (68.7) | 45.7 (74.3) | 35.9 (65.8) | 23.8 (64.5) | 45.2 (70.3) |
| Stickleback | 35.1 (65.9) | 28.1 (63.7) | 41.8 (71.1) | 35.8 (67.8) | 24.2 (62.9) | 44.4 (71.2) |
Alignments performed with lalign (https://www.ebi.ac.uk/Tools/psa/lalign/)70.