Table 4.
ncRNAs influence TIE via regulate EMT by targeting EMT- related transcription factors
| Target genes | ncRNAs | Function | Type of cancer | Refs. |
|---|---|---|---|---|
| Twist1 | ||||
| miR-543, 300, 186, 137, 720, 580, 539, 33a, 33b, 520d-5p, 106b, 675,337-3p and 151-5p | Inhibit EMT of tumor cells by targeting and downregulating Twist1, an EMT related transcription factor | Endometrial cancer, Epithelial ovarian cancer, Gastrointestinal stromal tumor, Breast cancer, Osteosarcoma, Melanoma, endometrial carcinoma, HCC, Lung carcinoma | 120,406–417 | |
| miR-23a, lncRNA AK027294, lncRNA ROR and lncRNA AFAP1-AS1 | Promote EMT of tumor cells by targeting and upregulating Twist1, an EMT related transcription factor | Tongue squamous cell carcinoma, Colorectal cancer, Gallbladder cancer | 121,418–420 | |
| Snail | ||||
| miR-21, 137, 34a, 491-5p, 22, 363, 30, 145, 153, 410-3p | Target and downregulate transcription factor Snail, and then inhibit EMT of tumor cells | Colorectal cancer, Ovarian cancer, Gastric cancer, Bladder cancer, Lung cancer, Osteosarcoma, HCC, Breast cancer | 117,118,421–427 | |
| miR-106a, circRNA 0084043, circRNA PRMT5, lncRNA PVT1 and lncRNA UCA1 | Target and upregulate transcription factor Snail, and then promote EMT of tumor cells | Glioma, Melanoma, Bladder carcinoma, Pancreatic cancer, Breast cancer | 119,122,124,428,429 | |
| ZEB1 | ||||
| miR-203, 873, 205-5p, 5702, 126, 186-5p | Target and downregulate transcription factor ZEB1, and then inhibit EMT of tumor cells | Gastric cancer, Breast cancer, Prostate cancer, NSCLC, Cervical cancer, Colorectal cancer | 430–435 | |
| lncRNA MALAT1, ZEB1-AS1, SNHG16, NNT-AS1, HOTTIP, NEAT1, ZNF469-3, TP73-AS1, circRNA TSPAN4 and circRNA PVT1 | Target and upregulate transcription factor ZEB1, and then promote EMT of tumor cells | HCC, NSCLC, Osteosarcoma, Breast cancer, Glioma, Nasopharyngeal carcinoma, Lung adenocarcinoma, Gastric cancer | 436–445 | |