Table 7.
ncRNAs transferred by TEX participate in TIE
ncRNAs transferred by TEX | Function | Tumor type | Refs. |
---|---|---|---|
miR-24-3p, 891a, 106a-5p, 20a-5p and 1908 | Promote T cell dysfunction by downregulating the MAPK1 pathway, thereby inhibiting the antitumor immunity and promote TIE | Nasopharyngeal carcinoma | 278 |
miR-214 and miR-214 | Promote the Treg phenotype by inhibiting PTEN in T cells, thereby inhibiting the antitumor immunity and promote TIE | Mouse lung cancer and sarcoma, NSCLC, Multiple myeloma | 279,472,473 |
miR-23a | Upregulates PD-L1 expression in macrophages and inhibits NK cells via downregulate CD107, thereby inhibiting the antitumor immunity and promote TIE | HCC, CML | 276,277 |
miR-212-3p | Inhibits antigen presentation process by downregulating MHC class II molecules in immature DC cells, thereby inhibiting the antitumor immunity and promote TIE | Pancreatic cancer | 474 |
miR-21 and miR-29a | Lead to the M2-type polarization of TAMs and promotes immunosuppression and TIE | NSCLC | 475,476 |
lncRNA ZFAS1 | Suppresses apoptosis of tumor cells and promotes the process of EMT, thereby promote TIE | Gastric cancer | 280 |
lncRNA UCA1 | Promotes the process of EMT, thereby promote TIE | Bladder cancer | 281 |
lncRNA MALAT1 | Promotes tumor growth, metastasis and inhibits tumor cell apoptosis, thereby promote TIE | Lung cancer | 282 |
CML chronic myeloid leukemia