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. 2020 Jun 19;5:102. doi: 10.1038/s41392-020-0194-y

Table 7.

ncRNAs transferred by TEX participate in TIE

ncRNAs transferred by TEX Function Tumor type Refs.
miR-24-3p, 891a, 106a-5p, 20a-5p and 1908 Promote T cell dysfunction by downregulating the MAPK1 pathway, thereby inhibiting the antitumor immunity and promote TIE Nasopharyngeal carcinoma 278
miR-214 and miR-214 Promote the Treg phenotype by inhibiting PTEN in T cells, thereby inhibiting the antitumor immunity and promote TIE Mouse lung cancer and sarcoma, NSCLC, Multiple myeloma 279,472,473
miR-23a Upregulates PD-L1 expression in macrophages and inhibits NK cells via downregulate CD107, thereby inhibiting the antitumor immunity and promote TIE HCC, CML 276,277
miR-212-3p Inhibits antigen presentation process by downregulating MHC class II molecules in immature DC cells, thereby inhibiting the antitumor immunity and promote TIE Pancreatic cancer 474
miR-21 and miR-29a Lead to the M2-type polarization of TAMs and promotes immunosuppression and TIE NSCLC 475,476
lncRNA ZFAS1 Suppresses apoptosis of tumor cells and promotes the process of EMT, thereby promote TIE Gastric cancer 280
lncRNA UCA1 Promotes the process of EMT, thereby promote TIE Bladder cancer 281
lncRNA MALAT1 Promotes tumor growth, metastasis and inhibits tumor cell apoptosis, thereby promote TIE Lung cancer 282

CML chronic myeloid leukemia