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. 2020 Jun 19;11:3135. doi: 10.1038/s41467-020-16872-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Degradation dynamics for each of the 19 amino acids included in the defined AA medium. b Clustering of time-resolved concentration values for the 19 amino acids analyzed. Error bars represent SD of two different cell cultures in two independent experiments. c Growth curve of the 19 amino acids experiment. Asterisks indicate growth lags. d Degradation dynamics for each of the four identified clusters of amino acids included in the defined AA medium. Colour codes as in b. Grey shaded area includes the 95% confidence of the linear regression (coloured) line over the concentrations of the amino acids belonging to the same group. Source data are provided as a Source Data file.