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. 2020 Jun 19;10:9968. doi: 10.1038/s41598-020-67036-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tracer kinetic curves showing the behaviour of the ligand PBR111 in implanted TSPO expressing glioma (red), compared to the ligand kinetics of PBR111 in the tissue of the surrounding brain (blue). (a) Wild-type host: The kinetics of [18 F]PBR111 demonstrate the increased retention of [18 F]PBR111 in the TSPO expressing syngeneic tumour (red), while healthy, normal cerebral tissue (blue) (excluding cerebellum) in Tspo+/+ animals has low to absent [18 F]PBR111 retention. ID = injected dose; n = 3; error bars denote standard deviation. (b) Knock-out host: Tspo−/− mice do not have any specific binding of [18 F]PBR111 in any organ. ID = injected dose; n = 3; error bars denote standard deviation.