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. 2020 Jun 19;10:9948. doi: 10.1038/s41598-020-67031-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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We enrolled 193 patients presented with cryptococcal meningitis from December 2001 to December 2013, 100 patients met the requirements according to inclusion criteria and were divided into two groups (CM-IRIS group and CM non-IRIS group) depends on whether IRIS developed or not and conducted comparative analysis of curative effectiveness. Furthermore we divided CM-IRIS group into two groups: CM-IRIS treated with GCs and CM-IRIS treated without GCs, and did comparative analysis of not only curative effectiveness but also incidence of IRIS.