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. 2020 Jun 19;10:10001. doi: 10.1038/s41598-020-66867-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Predicted survival curves by quartiles of age-adjusted germline mutation rates. Parental age and birth year were fixed to their median values (25 years and 1912, respectively) based on the fitted model in Table 1. (a) both sexes combined, all-cause mortality; (b) males only, all-cause mortality; (c) females only, non-cardiovascular disease (non-CVD) mortality. AAMRs: age-adjusted mutation rates, with quartiles color-coded as in Fig. 1.