. 2020 Jun 19;10:10001. doi: 10.1038/s41598-020-66867-0

Table 1.

Associations of germline mutation rates with mortality in 122 Generation I individuals.

	Age-adjusted germline mutation rates	All-cause mortality		CVD mortality		Non-CVD mortality
	Age-adjusted germline mutation rates	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p
Both sexes	Continuous	1.28 (1.05, 1.56)	*0.015*	1.14 (0.87, 1.49)	0.355	1.49 (1.12, 2.00)	*0.007*
	25^th-50^th percentile	1.51 (0.88, 2.59)	0.136	1.67 (0.79, 3.50)	0.177	1.41 (0.63, 3.14)	0.406
	>50^th-75^th percentile	1.59 (0.94, 2.70)	0.087	1.29 (0.57, 2.91)	0.545	2.07 (1.01, 4.24)	*0.047*
	> 75^th percentile	2.07 (1.21, 3.56)	*0.008*	1.28 (0.56, 2.93)	0.559	3.24 (1.57, 6.68)	*0.001*
	Trend test	1.25 (1.06, 1.48)	*0.009*	1.05 (0.82, 1.34)	0.694	1.48 (1.18, 1.87)	*0.001*
Males	Continuous	1.40 (1.04, 1.87)	*0.025*	1.39 (0.94, 2.07)	0.101	1.45 (0.94, 2.22)	0.092
	25^th-50^th percentile	1.24 (0.58, 2.65)	0.578	1.62 (0.55, 4.76)	0.383	1.11 (0.37, 3.37)	0.849
	>50^th-75^th percentile	1.80 (0.85, 3.83)	0.125	2.64 (0.86, 8.17)	0.091	1.45 (0.51, 4.14)	0.483
	> 75^th percentile	2.21 (1.03, 4.76)	*0.043*	2.39 (0.77, 7.46)	0.132	2.27 (0.79, 6.51)	0.126
	Trend test	1.32 (1.03, 1.68)	*0.026*	1.35 (0.96, 1.90)	0.084	1.31 (0.93, 1.85)	0.122
Females	Continuous	1.22 (0.93, 1.59)	0.158	0.74 (0.49, 1.12)	0.152	1.76 (1.24, 2.51)	*0.002*
	25^th-50^th percentile	2.04 (0.91, 4.59)	0.085	1.63 (0.56, 4.71)	0.368	2.17 (0.61, 7.64)	0.230
	>50^th-75^th percentile	1.44 (0.67, 3.10)	0.350	0.43 (0.11, 1.69)	0.225	2.91 (1.06, 8.03)	*0.039*
	> 75^th percentile	1.97 (0.88, 4.38)	0.097	0.41 (0.10, 1.60)	0.199	5.16 (1.79, 14.93)	*0.002*
	Trend test	1.18 (0.93, 1.50)	0.180	0.70 (0.47, 1.04)	0.081	1.68 (1.21, 2.33)	*0.002*

Associations with mortality of age-adjusted mutation rates (AAMRs) treated as a continuous or categorical variable were analyzed in both sexes combined and in each sex separately. In each section (Both sexes, Males, and Females) the first row (Continuous) presents the effects on the Hazard Ratio (HR) of a one standard deviation increase in AAMRs. The second, third, and fourth rows present the mortality risks for subjects with increasing quartiles of AAMRs, expressed relative to the mortality risks for the lowest quartile (<25^th percentile). The thresholds for the AAMRs are Males: 25% = −1.2385992, 50% = −0.1078028, 75% = 1.2402645; Females: 25% = −0.61610326, 50% = −0.09220471, 75% = 0.41736567. These thresholds were calculated using all 122 Generation I subjects. CI = Confidence Interval.