Table 2.

Associations of germline mutation rates with reproductive lifespan in 53 Generation I women with ALB ≥ 30 years.

Age-adjusted germline mutation rates	Number of live births				Age at last birth < 25th percentile
	Est	SE	Z	p	RR (95% CI)	p
Continuous	−0.12	0.08	−1.63	0.104	2.12 (1.05, 4.26)	0.036
≥33rd percentile	−0.27	0.11	−2.36	0.018	4.27 (0.81, 22.41)	0.086

Associations of AAMRs as a continuous or categorical variable with the number of live births and ALB for the 53 Generation I women with ALB ≥ 30 years. For the categorical analyses, women in the top two thirds of AAMRs were compared to women in the bottom third. Poisson regression was used to assess the association of AAMRs with the number of live births. Logistic regression models were used to assess the association of AAMRs with ALB. These associations were additionally adjusted for birth year of the Generation I woman, and whether she had any live births with missing birth dates in UPDB. The number of live births decreased by 8.73% for each standard deviation increase in the AAMRs (p = 0.104), and women in the top two thirds for AAMRs had significantly fewer live births than those in the bottom third for AAMRs (p = 0.018). The risk of the ALB being below the 25^th percentile increased 2.12 times for every standard deviation increase in the AAMRs (95% CI 1.05–4.26), p = 0.036). The 33^rd percentile cut point for AAMRs was −0.46200203. The 25^th percentile cut point for age at last birth was 34.8 years.