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. 2020 Jun 19;10:9964. doi: 10.1038/s41598-020-66472-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Representative diagram of the positive correlations between the toxic and essential elements that increase their concentration with age in human teeth dentine. Green nodes indicate essential elements. Red nodes indicate toxic elements. The thickness of the line indicates the degree of correlation. Fine line indicates a correlation is significant at the 0.05 level (2-tailed) and thick lines indicate that the correlation is significant at the 0.01 level (2-tailed). The size of the nodes represents the mean of the concentration of the element.