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. 2020 Jun 19;7:192. doi: 10.1038/s41597-020-0527-2

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© The Author(s) 2020

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Fig. 5 — Replication of differential gene expression between RTT and CTL brain. (a) Meta-analysis Z-Score compared to log2 fold change (FC) between RTT and CTL from our initial analysis (GEO), Lin et al. combined frontal and temporal cortex (from Table S5)¹³, Gogliotti et al. motor cortex (from Table S2)¹⁴, and Gogliotti et al. cerebellum (from Table S3)¹⁴. Genes with significant differential expression (False Discovery Rate [FDR] < 0.05) in the dataset represented on the X-axis are in red. (b) Spearman’s correlation between meta-analysis Z-score and logFC for each of the other datasets. Color intensity and circle size are proportional to the correlation coefficients with values displayed below the diagonal. (c) Density of gene-wise correlation coefficients among datasets in (b).