Table 3.

Human MLKL brace helix compound heterozygotes in CRMO vs healthy controls.

Population	Frequency of relevant compound Hetsa in CRMO	Frequency of relevant compound Hetsa in healthy controls	CRMO:Healthyb	2 tailed P value (Fisher’s exact)	2 tailed P value (chi square with Yate’s)
Globalc	0.023 (3/128)	0.0008 (2/2504) NIH 1KG	29:1	0.001	0.0001
Europeand	0.02 (2/101)	0.002 (1/503) NIH 1KG	10:1	0.074	0.1215
Europeand	0.02 (2/101)	0.0017 (25/14,542) QUT controls	12:1	n/a	0.0022

^aCombinations of R146Q – rs34515646, S132P – rs35589326 and G202*V – rs144526386 (Fig. 5e).

^bFrequency ratio rounded to nearest whole number.

^cCRMO patients and healthy controls of all ancestries included.

^dCRMO patients and healthy controls of only European descent included.