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. 2020 Jun 19;8:25. doi: 10.1038/s41413-020-0100-9

Table 3.

The exosomal miRNAs in OA

Exosomes miRNAs Exosomes source Target gene Biological effects Reference
miR-92a-3p BMSCs WNT5A Promote cell proliferation and increase matrix synthesis in OA primary chondrocytes. 190
miR-26a-5p BMSCs PTGS2 Promote the survival of synovial fibroblasts and reduce synovitis in Rat OA model. 186
miR-135b EMSCs Sp1 Enhance chondrocyte proliferation in vitro and promote cartilage repair in vivo. 221
miR-100-5p AMSCsSHEDs mTOR

Initiate autophagy and restore cartilage anabolism, inhibit catabolism in chondrocytes.

Prevent cartilage erosion and suppression of inflammation in experimental OA model.

146,224
miR-140-5p SMSCs RalA Increase the expression of SOX9 and Aggrecan of chondrocytes and maintain ECM secretion. 122
miR-95-5p Chondrocytes HDAC2/8 Increase the level of acetylated histone H3, and maintain cartilage development and homeostasis in vitro. 109
miR-449a-5p Chondrocytes ATG4B

Inhibit autophagy inhibition and activate inflammasome in macrophages.

Promote cartilage erosion and synovitis in DMM-induced OA mice.

107
miR-8485 Chondrocytes GSK3β Induce chondrogenic differentiation of BMSCs via GSK-3β-mediated Wnt/β-catenin pathway. 111