Table 3.
The exosomal miRNAs in OA
| Exosomes miRNAs | Exosomes source | Target gene | Biological effects | Reference |
|---|---|---|---|---|
| miR-92a-3p | BMSCs | WNT5A | Promote cell proliferation and increase matrix synthesis in OA primary chondrocytes. | 190 |
| miR-26a-5p | BMSCs | PTGS2 | Promote the survival of synovial fibroblasts and reduce synovitis in Rat OA model. | 186 |
| miR-135b | EMSCs | Sp1 | Enhance chondrocyte proliferation in vitro and promote cartilage repair in vivo. | 221 |
| miR-100-5p | AMSCsSHEDs | mTOR |
Initiate autophagy and restore cartilage anabolism, inhibit catabolism in chondrocytes. Prevent cartilage erosion and suppression of inflammation in experimental OA model. |
146,224 |
| miR-140-5p | SMSCs | RalA | Increase the expression of SOX9 and Aggrecan of chondrocytes and maintain ECM secretion. | 122 |
| miR-95-5p | Chondrocytes | HDAC2/8 | Increase the level of acetylated histone H3, and maintain cartilage development and homeostasis in vitro. | 109 |
| miR-449a-5p | Chondrocytes | ATG4B |
Inhibit autophagy inhibition and activate inflammasome in macrophages. Promote cartilage erosion and synovitis in DMM-induced OA mice. |
107 |
| miR-8485 | Chondrocytes | GSK3β | Induce chondrogenic differentiation of BMSCs via GSK-3β-mediated Wnt/β-catenin pathway. | 111 |