Table 2.
The diagnostic performance of the developed system for detecting osteoporosis and distinguishing low BMD from normal bone mass, using QCT as the reference standard
| Diagnosis | AUC (95% CI) | Sensitivity (n/N) | Specificity (n/N) | PPV (n/N) | NPV (n/N) |
|---|---|---|---|---|---|
| Women (n = 178) | |||||
| Osteoporosis | 0.950 (0.907–0.977) | 90.70% (39/43) | 99.26% (134/135) | 97.50% (39/40) | 97.10% (134/138) |
| Low BMD | 0.933 (0.885–0.965) | 90.00% (108/120) | 96.55% (56/58) | 98.18% (108/110) | 82.35% (56/68) |
| Men (n = 196) | |||||
| Osteoporosis | 0.875 (0.820–0.918) | 75.00% (15/20) | 100.00% (176/176) | 100.00% (15/15) | 97.24% (176/181) |
| Low BMD | 0.949 (0.908–0.975) | 90.82% (89/98) | 98.98% (97/98) | 98.89% (89/90) | 91.51% (97/106) |
| Total (n = 374) | |||||
| Osteoporosis | 0.927 (0.896–0.951) | 85.71% (54/63) | 99.68% (310/311) | 98.18% (54/55) | 97.18% (310/319) |
| Low BMD | 0.942 (0.914–0.964) | 90.37% (197/218) | 98.08% (153/156) | 98.50% (197/200) | 87.93% (153/174) |