Table 2.
The application of HDAC inhibitors to B-cell lymphoma (BCL)
| Names | Potential mechanisms of action | Target (HDAC) | Subtype |
|---|---|---|---|
| Apicidin | Upregulate MHC I and II | HDAC3/6 | DLBCL |
| Belinostat | Induce cell death, upregulate MHC I and II | HDAC1/2/3/4/5/6/7/8/9/10/11 | DLBCL, MCL, FL, TL, HG-BCL, BL, PMBCL |
| Citarinostat | Induce cell death | HDAC6 | FL, MCL, HL |
| CI-994 | Induce cell death | HDAC1/3 | PEL, canine BCL |
| Entinostat | Induce cell death, upregulate MHC I and II, CD20, reduce MDSC | HDAC1/2/3/10 | HL, NHL, DLBCL, BL |
| MC1568 | CD1d-mediated antigen presentation | HDAC4/5/6/7/9/10 | MCL |
| Mocetinostat | Induce cell death, upregulate PD-L1 | HDAC1/2/3/11 | HL, DLBCL, FL |
| MPT0E028 | Induce cell death | HDAC1/2/6 | BL |
| OKI-5/OKI-179 | Induce cell death, upregulate PD-L1, MHC I and II | HDAC1/2/3/6/8/10/11 | DLBCL, murine BCL |
| Panobinostat | Induce cell death, CD1d-mediated antigen presentation, upregulate PD-L1, inhibit CD4/8 T cells | HDAC1/2/3/4/5/6/7/8/9/10/11 | HL, DLBCL, MCL, BL, murine and canine BCL |
| RGFP966 | Induce cell death, upregulate MHC I, CD80, CD86, PD-L1 | HDAC3 | DLBCL, murine BCL |
| Ricolinostat | Induce cell death | HDAC6 | DLBCL, MCL, FL |
| Romidepsin | Induce cell death, upregulate MHC I, CD80, CD86, CD20, NKG2D ligands | HDAC1/2 | BL, DLBCL, MCL, murine BCL |
| SBHA | Induce cell death | HDAC1/3 | MCL, PEL, canine BCL |
| Scriptaid | Induce cell death | HDAC1/3/8 | DLBCL, canine BCL |
| Sodium butyrate | Induce cell death, upregulate MHC I and II | HDAC1/2/3 | BL, FL, PEL, DLBCL |
| Trichostatin A | Induce cell death, upregulate MHC I and II, MHC II-mediated antigen presentation, CD1d-mediated antigen presentation, upregulate PD-L1, activate Tregs | HDAC1/2/3/6/8/10/11 | DLBCL, MCL, murine and canine BCL |
| Tubacin | Induce cell death, activate Tregs | HDAC6 | BL, canine BCL |
| Tubastatin A | Induce cell death, activate Tregs | HDAC6 | DLBCL, MCL |
| Valproic acid | Induce cell death, upregulate MHC I and II, CD80, CD86, PD-L1, CD20, activate Tregs | HDAC1/2 | BL, DLBCL, MCL, murine BCL |
| Vorinostat | Induce cell death, upregulate PD-L1, activate Tregs | HDAC1/2/3/5/6/8/9/10/11 | FL, DLBCL, HL, MCL, iNHL, BL, murine and canine BCL |
BL: Burkitt lymphoma; DLBCL: diffuse large B-cell lymphoma; FL: follicular lymphoma; HG-BCL: high grade B-cell lymphoma; HL: Hodgkin lymphoma; iNHL: indolent NHL; MCL: mantle cell lymphoma; NHL: non-Hodgkin lymphoma; PEL: primary effusion lymphoma; PMBCL: primary mediastinal B-cell lymphoma; TL: transformed lymphoma