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. 2020 Jun 15;14:2371–2379. doi: 10.2147/DDDT.S239273

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© 2020 Gu et al.

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GW9508 inhibited AGE-induced expression and secretion of ADAMTS-4 and ADAMTS-5 in human SW1353 chondrocytes. Cells were treated with AGEs (100 μg/mL) in the presence or absence of GW9508 (25 and 50 μM) for 24 h. (A) mRNA of ADAMTS-4 and ADAMTS-5; (B) Secretions of ADAMTS-4 and ADAMTS-5 (***, P<0.0001 vs. control group; *, **, P<0.01, 0.001 vs. AGE treatment group).