Table 2.

Comparison of the OR diffusion metrics between HCs and MS patients.

Diffusion MR metrics	HC	MS		p-value
		NAWM	Lesion	HC vs NAWM	NAWM vs Lesion
DTI
FA	0.52 (0.02)	0.49 (0.041)	0.36 (0.08)	<0.001*	<0.001*
MD (×10−3)	0.91 (0.04)	1.01 (0.19)	1.26 (0.19)	0.014*	<0.001*
AD (×10−3)	1.50 (0.06)	1.59 (0.29)	1.76 (0.24)	0.1	0.03*
RD (×10−3)	0.61 (0.04)	0.71 (0.16)	1.00 (0.19)	0.003*	<0.001*
WMTI
AWF	0.39 (0.02)	0.36 (0.03)	0.27 (0.03)	<0.001*	<0.001*
Da	1.05 (0.06)	1.04 (0.06)	0.99 (0.17)	0.7	0.13
De, perp	1.03 (0.05)	1.09 (0.14)	1.4 (0.28)	0.02*	<0.001*
De, ||	2.36 (0.09)	2.36 (0.19)	2.44 (0.38)	0.9	0.4
Tort	2.48 (0.17)	2.33 (0.21)	1.77 (0.29)	0.004*	<0.001*

Note. – Diffusion metric differences between MS from HCs were assessed using Student’s t tests. Mean values are reported with standard deviations shown in parentheses.

^*Denotes significance following correction for multiple comparisons (FDR threshold of 0.05). Raw p-values are reported in the table.