Table 2.
Demographic and clinical comparisons of patients above and below the path length time-variance threshold, separately for FO and UO; the number of patients for which values were not available are shown in parentheses. Statistical results are shown based on t-statistic or Fisher’s exact test. ROSC = Return of spontaneous circulation; FOUR = Full Outline of UnResponsiveness; SSEP = Somatosensory evoked potentials.
| Path length time-variance |
|||
|---|---|---|---|
| Above threshold | Below threshold | p-value | |
| Favorable outcome | |||
| N | 26 | 31 | |
| Time to ROSC (min), M ± SD | 19.11 ± 14.28 | 22.25 ± 13.66 | 0.41 |
| Age (y), M ± SEM | 57.76 ± 15.87 | 65.90 ± 13.70 | 0.05 |
| Gender (male), N (Nmissing) | 22 (0) | 26(0) | 1 |
| Time to 1st EEG (h), M ± SEM | 18.85 ± 6.92 | 21.76 ± 5.34 | 0.10 |
| Time from 1st to 2nd EEG (h), M ± SD | 23.84 ± 3.02 | 22.51 ± 2.77 | 0.16 |
| Temperature (°C), M ± SEM | 35.61 ± 0.85 | 35.64 ± 1.11 | 0.92 |
| Propofol (mg/kg/h), M ± SD (n) | 2.46 ± 1.53 (21) | 2.54 ± 0.74 (23) | 0.85 |
| Midazolam (mg/kg/h), M ± SD (n) | 0.13 ± 0.05 (12) | 0.11 ± 0.05 (8) | 0.46 |
| Fentanyl (μg/kh/h), M ± SD (n) | 0.89 ± 0.46 (20) | 1.55 ± 1.49 (22) | 0.07 |
| FOUR score | 4.83 ± 2.76 | 4.85 ± 1.79 | 0.99 |
| Eye | 0 ± 0 | 0 ± 0 | |
| Motor | 0.86 ± 1.36 | 0.20 ± 0.60 | 0.30 |
| Brainstem | 2.57 ± 0.90 | 3.30 ± 1.10 | 0.18 |
| Respiratory | 0.57 ± 0.49 | 0.60 ± 0.49 | 0.91 |
| EEG reactivity 1st day, N (Nmissing) | 5 (6) | 5 (3) | 0.72 |
| EEG discontinuity 1st day, N (Nmissing) | 4 (1) | 14 (1) | 0.02 |
| Electrographic epileptic activity 1st day, N(Nmissing) | 0 (1) | 1 (1) | 1 |
| Pulmonary etiology of CA, N (Nmissing) | 6 (0) | 5 (0) | 0.52 |
| Pupillary reflexes, N (Nmissing) | 20 (6) | 25 (3) | 0.25 |
| Corneal reflexes, N (Nmissing) | 18 (6) | 23 (3) | 0.68 |
| Motor response, N (Nmissing) | 14 (6) | 22 (3) | 0.52 |
| SSEP absence, N (Nmissing) | 0 (14) | 0 (15) | |
| Unfavorable outcome | |||
| N | 6 | 35 | |
| ROSC (min), M ± SD | 34.16 ± 14.55 | 28.22 ± 13.78 | 0.42 |
| Age (y), M ± SEM | 59.66 ± 10.27 | 66.00 ± 13.42 | 0.25 |
| Gender (male), N (Nmissing) | 4 (0) | 23 (0) | 1 |
| Time to 1st EEG (h), M ± SEM | 22.83 ± 5.84 | 20.07 ± 7.03 | 0.37 |
| Time from 1st to 2nd EEG (h), M ± SD | 23.80 ± 1.32 | 24.08 ± 4.99 | 0.81 |
| Temperature (°C), M ± SEM | 36.22 ± 0.51 | 35.82 ± 0.91 | 0.18 |
| Propofol (mg/kg/h), M ± SD (n) | 3.08 ± 1.024 (6) | 2.18 ± 1.41 (13) | 0.20 |
| Midazolam (mg/kg/h), M ± SD (n) | 0.03 ± 0.02 (2) | 0.09 ± 0.05 (16) | 0.04 |
| Fentanyl (μg/kh/h), M ± SD (n) | 0.50 ± 0.24 (3) | 1.06 ± 0.73 (17) | 0.05 |
| FOUR | 2.40 ± 1.62 | 2.38 ± 2.04 | 0.98 |
| Eye | 0 ± 0 | 0.08 ± 0.27 | 0.34 |
| Motor | 0 ± 0 | 0.46 ± 1.08 | 0.17 |
| Brainstem | 2.00 ± 1.41 | 2.15 ± 1.50 | 0.87 |
| Respiratory | 0.50 ± 0.50 | 0.62 ± 0.49 | 0.74 |
| EEG reactivity 1st day, N (Nmissing) | 5 (1) | 25 (7) | 1 |
| EEG discontinuity 1st day, N (Nmissing) | 5 (0) | 26 (3) | 1 |
| Electrographic epileptic activity 1st day, N (Nmissing) | 6 (0) | 13 (3) | 0.02 |
| Pulmonary etiology of CA, N (Nmissing) | 2 (0) | 5 (3) | 0.30 |
| Pupillary reflexes, N (Nmissing) | 3 (1) | 18 (10) | 0.62 |
| Corneal reflexes, N (Nmissing) | 3 (1) | 9 (10) | 0.36 |
| Motor response, N (Nmissing) | 1 (1) | 2 (10) | 0.43 |
| SSEP absence, N (Nmissing) | 3 (3) | 9 (18) | 0.24 |