Figure 3.

(A) Ascites fluid accumulation and peritoneal carcinomatosis tumors were observed in Pten^d/d Trp53^d/d TgK19GT₁₂₁ and Pten^d/d Trp53^d/d Cdh1^d/d TgK19GT₁₂₁ mice. White arrows show primary ovarian tumors and black arrows show extensive peritoneal carcinomatosis with clusters of tumor nodules. (B) Overall survival rate for control, Cdh1^d/d, TgK19GT₁₂₁, Pten^d/d Trp53^d/d, Pten^d/d Trp53^d/d Cdh1^d/d, Pten^d/d Trp53^d/d TgK19GT₁₂₁, and Pten^d/d Trp53^d/d Cdh1^d/d TgK19GT₁₂₁ mice was determined by Kaplan–Meier analysis (P < 0.0001). All mice were monitored for any sign of sickness or discomfort. When present, those mice were euthanized, and the day of sacrifice was recorded. Black arrow shows that more mice with Pten^d/d Trp53^d/d TgK19GT₁₂₁ died by 4.5 months compared to mice with Pten^d/d Trp53^d/d Cdh1^d/d TgK19GT₁₂₁.